Structure of PDB 5cob Chain D

Receptor sequence

>5cobD (length=365) Species: 4058 (Catharanthus roseus)

MAKSYKSVALVVGVTGIVGSSLAEVLKLPDTPGGPWKVYGVARRPCPVWL
AKKPVEYIQCDVSDNQETISKLSPLKDITHIFYVSWIGSEDCQTNATMFK
NILNSVIPNASNLQHVCLQTGIKHYFGIFEEGSKVVPHDSPFTEDLPRLN
VPNFYHDLEDILYEETGKNNLTWSVHRPALVFGFSPCSMMNIVSTLCVYA
TICKHENKALVYPGSKNSWNCYADAVDADLVAEHEIWAAVDPKAKNQVLN
CNNGDVFKWKHIWKKLAEEFGIEMVGYVEGKEQVSLAELMKDKDQVWDEI
VKKNNLVPTKLKEIAAFWFADIAFCSENLISSMNKSKELGFLGFRNSMKS
FVSCIDKMRDYRFIP

3D structure

• PDB: 5cob Structure of iridoid synthase in complex with NADP(+)/8-oxogeranial reveals the structural basis of its substrate specificity.
• Chain: D
• Resolution: 2.65 Å

Enzymatic activity

• Enzyme Commision number: 1.3.1.122: (S)-8-oxocitronellyl enol synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	D	G36 T38 G39 I40 A65 R66 R67 C83 D84 V85 V107 S108 W109 Q142 T143 Y178 P201 A202 V204 S211 M212 M213	G13 T15 G16 I17 A42 R43 R44 C60 D61 V62 V84 S85 W86 Q119 T120 Y155 P178 A179 V181 S188 M189 M190
BS02	XOG	D	G144 I145 K146 F149 Y178 M213 I345 S349	G121 I122 K123 F126 Y155 M190 I322 S326

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
• GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
• GO:0042802 identical protein binding
• GO:0042803 protein homodimerization activity

Biological Process

• GO:0016099 monoterpenoid biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:5cob, PDBe:5cob, PDBj:5cob
• PDBsum: 5cob
• PubMed: 26868105
• UniProt: K7WDL7|IRIS_CATRO (S)-8-oxocitronellyl enol synthase