Structure of PDB 5cg9 Chain D

Receptor sequence

>5cg9D (length=264) Species: 5762 (Naegleria gruberi) [Search protein sequence]

INKKSLLQNLLSKCKTTFQQSFTNANITLKDEKWLKNVRTAYFVCDHDGS
VELAYLPNVLPKELVEEFTEKFESIQTGRKKDTGYSGILDNSMPFNYVTA
DLSQELGQYLSEIVNPQINYYISKLLTCVSSRTINYLVSLNDSYYALNNC
LYPSTAFNSLKPSNDGHRIRKPHKDNLDITPSSLFYFGNFQNTEGYLELT
DKNCKVFVQPGDVLFFKGNEYKHVVANITSGWRIGLVYFAHKGSKTKPYY
EDTQKNSLKIHKET

3D structure

PDB

5cg9 Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA.

Chain

Resolution

2.693 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.11.80: methylcytosine dioxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	D	S148 M149 P150 N232	S92 M93 P94 N176
BS02	dna	D	Y141 Y153 T155 A156 R224 D234 V293 F295 H297 Q310	Y85 Y97 T99 A100 R168 D178 V237 F239 H241 Q254
BS03	AKG	D	N214 R224 H229 D231 L240 Y242 L253 H279 V281 R289 V293	N158 R168 H173 D175 L184 Y186 L197 H223 V225 R233 V237
BS04	MN	D	H229 D231 H279	H173 D175 H223

External links

PDB	RCSB:5cg9, PDBe:5cg9, PDBj:5cg9
PDBsum	5cg9
PubMed	26323320
UniProt	D2W6T1\|TET1_NAEGR Tet-like dioxygenase 1 (Gene Name=TET1)

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