Structure of PDB 5cb4 Chain D

Receptor sequence

>5cb4D (length=421) Species: 41807 (Sus barbatus)

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVY
YNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNN
WAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTL
LISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETY
CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADL
RKLAVNMVPFPRLHFFMPGFAPLLTVPELTQQMFDSKNMMAACDPRHGRY
LTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTE
AESNMNDLVSEYQQYQDATAD

3D structure

• PDB: 5cb4 Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.
• Chain: D
• Resolution: 2.193 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GDP	D	G10 Q11 C12 Q15 S138 G141 T143 G144 S176 E181 N204 Y222 N226	G10 Q11 C12 Q15 S138 G141 T143 G144 S176 E181 N204 Y222 N226
BS02	TIV	D	C239 L246 A248 K252 L253 N256 M257 A314 A315 I316 N348 K350 A352 I368	C239 L246 A248 K252 L253 N256 M257 A304 A305 I306 N338 K340 A342 I358

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005200 structural constituent of cytoskeleton
• GO:0005525 GTP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0000226 microtubule cytoskeleton organization
• GO:0000278 mitotic cell cycle
• GO:0007017 microtubule-based process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule

External links

• PDB: RCSB:5cb4, PDBe:5cb4, PDBj:5cb4
• PDBsum: 5cb4
• PubMed: 26462166
• UniProt: A0A0R4I995