Structure of PDB 5c5x Chain D

Receptor sequence
>5c5xD (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
KKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGL
AIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAG
AGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTD
SRRTEPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSP
AHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIKGTYEP
3D structure
PDB5c5x Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways.
ChainD
Resolution2.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PS6 D P157 V158 G159 S160 L163 P156 V157 G158 S159 L162
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015250 water channel activity
GO:0015267 channel activity
GO:0042802 identical protein binding
Biological Process
GO:0006833 water transport
GO:0015670 carbon dioxide transport
GO:0030157 pancreatic juice secretion
GO:0042476 odontogenesis
GO:0046541 saliva secretion
GO:0048593 camera-type eye morphogenesis
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0071476 cellular hypotonic response
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5c5x, PDBe:5c5x, PDBj:5c5x
PDBsum5c5x
PubMed26569106
UniProtP55064|AQP5_HUMAN Aquaporin-5 (Gene Name=AQP5)

[Back to BioLiP]