Structure of PDB 5bti Chain D

Receptor sequence
>5btiD (length=247) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
NALVRRKSGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAI
LPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIV
LMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDP
EFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDP
SVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV
3D structure
PDB5bti Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
ChainD
Resolution2.501 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D K484 I486 N487 K490 R495 N499 H539 V656 R659 K56 I58 N59 K62 R67 N71 H111 V228 R231
BS02 dna D E459 D461 D536 E31 D33 D108
BS03 dna D K484 N487 K490 R495 N499 H539 V656 R659 K56 N59 K62 R67 N71 H111 V228 R231
BS04 dna D E459 D461 G483 K484 D536 E31 D33 G55 K56 D108
BS05 MG D D532 D534 D104 D106
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5bti, PDBe:5bti, PDBj:5bti
PDBsum5bti
PubMed26792525
UniProtP9WG45|GYRB_MYCTU DNA gyrase subunit B (Gene Name=gyrB)

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