Structure of PDB 5ao1 Chain D

Receptor sequence
>5ao1D (length=442) Species: 9606 (Homo sapiens) [Search protein sequence]
PGMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARD
CHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSL
HRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAY
TKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIK
REDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDKNPIDHVSFYCKT
APNRAIEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQ
3D structure
PDB5ao1 Phospho-Dependent Regulation of Samhd1 Oligomerisation Couples Catalysis and Restriction.
ChainD
Resolution2.545 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DG3 D Y155 V156 V378 R451 Y43 V44 V259 R332
BS02 FE D H167 H206 D207 D311 H55 H94 D95 D192
BS03 DG3 D R164 H206 D207 H210 H215 H233 D311 Y315 R52 H94 D95 H98 H103 H121 D192 Y196
BS04 DG3 D K116 I118 D137 R145 K4 I6 D25 R33
External links
PDB RCSB:5ao1, PDBe:5ao1, PDBj:5ao1
PDBsum5ao1
PubMed26431200
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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