Structure of PDB 5acb Chain D

Receptor sequence
>5acbD (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]
DWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGF
PITAIREIKILRQLIHRSVVNMKEIVTDKQFKKDKGAFYLVFEYMDHDLM
GLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSG
QIKLADFGLARLYNSRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC
ILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKP
KKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVE
LSKMAPPDLPHWQDCHELWS
3D structure
PDB5acb Covalent Targeting of Remote Cysteine Residues to Develop Cdk12 and Cdk13 Inhibitors.
ChainD
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D859 K861 S863 N864 D877 T898
Catalytic site (residue number reindexed from 1) D138 K140 S142 N143 D156 T174
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5I1 D I733 V741 A754 K756 F813 M816 D819 E825 Q1037 C1039 E1041 I16 V24 A37 K39 F92 M95 D98 E104 Q313 C315 E317
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5acb, PDBe:5acb, PDBj:5acb
PDBsum5acb
PubMed27571479
UniProtQ9NYV4|CDK12_HUMAN Cyclin-dependent kinase 12 (Gene Name=CDK12)

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