Structure of PDB 4zm9 Chain D

Receptor sequence
>4zm9D (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
GNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEG
AVVALEDDPEFNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIAN
PIKLARLVMEKTPHCFLTDQGAAQFAAAMGVPEIPGEKLVTERNKKRLEK
EKHETVGAVALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADNDI
GAVSTTGHGESILKVNLARLTLFHIEQGKTVEEAADLSLGYMKSRVKGLG
GLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPDDTTITDLPG
3D structure
PDB4zm9 Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages.
ChainD
Resolution2.51 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N62 T168 T186 R196 T219 G220
Catalytic site (residue number reindexed from 1) N62 T155 T173 R183 T206 G207
Enzyme Commision number 3.4.19.5: beta-aspartyl-peptidase.
3.5.1.1: asparaginase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLY D R196 D199 G220 G222 R183 D186 G207 G209
Gene Ontology
Molecular Function
GO:0004067 asparaginase activity
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:4zm9, PDBe:4zm9, PDBj:4zm9
PDBsum4zm9
PubMed26780688
UniProtQ7L266|ASGL1_HUMAN Isoaspartyl peptidase/L-asparaginase (Gene Name=ASRGL1)

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