Structure of PDB 4zla Chain D

Receptor sequence
>4zlaD (length=480) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
MLKIKLEKTTFENAKAECSLVFIINKDFSHAWVKNKELLETFKYEGEGVF
LDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCALLE
NLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKLEKSAKEALKY
AEIMTESLNIVKDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFL
EEKKMNAFLAVNKASLSVNPPRLIHLVYKPKKAKKKIALVGKGLTYDCGG
LSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIG
PAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFA
TLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKK
LIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYV
EKEWDVNSFGASGAGVRACTAFVEELLKKA
3D structure
PDB4zla Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase.
ChainD
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K270 R344
Catalytic site (residue number reindexed from 1) K254 R328
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.11.10: bacterial leucyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D K258 D263 D281 E342 K242 D247 D265 E326
BS02 ZN D D263 D340 E342 D247 D324 E326
BS03 NA D A461 G462 Y465 A445 G446 Y449
BS04 BCT D A341 E342 G343 R344 L368 A325 E326 G327 R328 L352
BS05 BES D K258 D263 D281 D340 E342 T367 L368 T369 G370 A461 K242 D247 D265 D324 E326 T351 L352 T353 G354 A445 MOAD: ic50=49.9nM
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:4zla, PDBe:4zla, PDBj:4zla
PDBsum4zla
PubMed26616008
UniProtO25294|AMPA_HELPY Cytosol aminopeptidase (Gene Name=pepA)

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