Structure of PDB 4zkl Chain D

Receptor sequence

>4zklD (length=113) Species: 9606 (Homo sapiens) [Search protein sequence]

GGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQI
SVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHL
HVLGGRQMHWPPG

3D structure

PDB

4zkl Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.

Chain

Resolution

2.34 Å

3D
structure

Enzymatic activity

Enzyme Commision number

3.4.22.-
3.9.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	JB6	D	D43 I44 S107 V108 H114	D30 I31 S94 V95 H101
BS02	AMP	D	D43 I44 N99 G105 Q106 S107 H112 H114	D30 I31 N86 G92 Q93 S94 H99 H101

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0016787	hydrolase activity
GO:0016929	deSUMOylase activity
GO:0043530	adenosine 5'-monophosphoramidase activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0009154	purine ribonucleotide catabolic process
GO:0016926	protein desumoylation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

	Cellular Component
GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0070062	extracellular exosome

External links

PDB	RCSB:4zkl, PDBe:4zkl, PDBj:4zkl
PDBsum	4zkl
PubMed	26905466
UniProt	P49773\|HINT1_HUMAN Adenosine 5'-monophosphoramidase HINT1 (Gene Name=HINT1)