Structure of PDB 4zi6 Chain D

Receptor sequence
>4zi6D (length=479) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
MLKIKLEKTTFENAKAECSLVFIINKDFSHAWVKNKELLETFKYEGEGVF
LDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTALLEN
LKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHSLEKSAKEALKYA
EIMTESLNIVKDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFLE
EKKMNAFLAVNKASLSVNPPRLIHLVYKPKKAKKKIALVGKGLTYDCGGL
SLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGP
AAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFAT
LTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKL
IESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVE
KEWDVNSFGASGAGVRACTAFVEELLKKA
3D structure
PDB4zi6 Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase.
ChainD
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K270 R344
Catalytic site (residue number reindexed from 1) K253 R327
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.11.10: bacterial leucyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D K258 D263 D281 E342 K241 D246 D264 E325
BS02 ZN D D263 D340 E342 D246 D323 E325
BS03 BCT D A341 E342 G343 R344 L368 A324 E325 G326 R327 L351
BS04 NA D A461 G462 Y465 A444 G445 Y448
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zi6, PDBe:4zi6, PDBj:4zi6
PDBsum4zi6
PubMed26616008
UniProtO25294|AMPA_HELPY Cytosol aminopeptidase (Gene Name=pepA)

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