Structure of PDB 4zcs Chain D

Receptor sequence
>4zcsD (length=139) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
KNVVIYADGVYDMLHLGHMKQLEQAKKLFENTTLIVGVTSDNETKLFKGQ
VVQTLEERTETLKHIRWVDEIISPCPWVVTPEFLEKYKIDYVAHDDIPYA
NNQKEDIYAWLKRAGKFKATQRTEGVSTTDLIVRILKNY
3D structure
PDB4zcs Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis.
ChainD
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) F662 G664
Catalytic site (residue number reindexed from 1) F47 G49
Enzyme Commision number 2.7.7.15: choline-phosphate cytidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CDC D D623 G624 V625 Y626 H630 G632 H633 Q636 T654 K663 W692 H709 D710 Y714 Y741 R755 T756 D8 G9 V10 Y11 H15 G17 H18 Q21 T39 K48 W77 H94 D95 Y99 Y108 R122 T123
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004105 choline-phosphate cytidylyltransferase activity
Biological Process
GO:0006657 CDP-choline pathway
GO:0009058 biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4zcs, PDBe:4zcs, PDBj:4zcs
PDBsum4zcs
PubMed30046154
UniProtQ8IEE9

[Back to BioLiP]