Structure of PDB 4z2d Chain D

Receptor sequence
>4z2dD (length=194) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
MKSGLEIPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPI
RGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMT
DADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPLGEMDDHQLWETTM
DPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVYS
3D structure
PDB4z2d Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
ChainD
Resolution3.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y643
Catalytic site (residue number reindexed from 1) Y193
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D G457 K458 D510 G52 K53 D105
BS02 dna D N461 H513 V630 R633 N56 H108 V180 R183
BS03 dna D G434 D435 G29 D30
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4z2d, PDBe:4z2d, PDBj:4z2d
PDBsum4z2d
PubMed
UniProtP0A4M0|GYRB_STRR6 DNA gyrase subunit B (Gene Name=gyrB)

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