Structure of PDB 4z0c Chain D

Receptor sequence

>4z0cD (length=709) Species: 10090 (Mus musculus) [Search protein sequence]

YGFNKCTQYEFDIHHVLCIRKKITNLTEAISDIPRYTTHLNLTHNEIQVL
PPWSFTNLSALVDLRLEWNSIWKIDEGAFRGLENLTLLNLVENKIQSVNN
SFEGLSSLKTLLLSHNQITHIHKDAFTPLIKLKYLSLSRNNISDFSGILE
AVQHLPCLERLDLTNNSIMYLDHSPRSLVSLTHLSFEGNKLRELNFSALS
LPNLTNLSASRNGNKVIQNVYLKTLPQLKSLNLSGTVIKLENLSAKHLQN
LRAMDLSNWELRHGHLDMKTVCHLLGNLPKLETLVFQKNVTNAEGIKQLA
KCTRLLFLDLGQNSDLIYLNDSEFNALPSLQKLNLNKCQLSFINNRTWSS
LQNLTSLDLSHNKFKSFPDFAFSPLKHLEFLSLSRNPITELNNLAFSGLF
ALKELNLAACWIVTIDRYSFTQFPNLEVLDLGDNNIRTLNHGTFRPLKKL
QSLILSHNCLKILEPNSFSGLTNLRSLDLMYNSLSYFHEHLFSGLEKLLI
LKLGFNKITYETTRTLQYPPFIKLKSLKQLNLEGQRHGIQVVPSNFFQGL
GSLQELLLGKNPSVFLDHHQFDPLINLTKLDISGTKDGDRSLYLNASLFQ
NLKRLKILRLENNNLESLVPDMFSSLQSLQVFSLRFNNLKVINQSHLKNL
KSLMFFDVYGNKLQCTCDNLWFKNWSMNTEEVHIPFLRSYPCQQPGSQSL
LIDFDDAMC

3D structure

PDB

4z0c Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	D	E579 T580 R582 H605 Q608 V609 F633 D635 R658	E511 T512 R514 H537 Q540 V541 F565 D567 R590
BS02	rna	D	Y77 H83 L85 R88 W136 E160 H183 R207 S524 H525 D546 M548 Y549 K570 E601 R677 E679 N680 R703 F704	Y9 H15 L17 R20 W68 E92 H115 R139 S456 H457 D478 M480 Y481 K502 E533 R609 E611 N612 R635 F636

External links

PDB	RCSB:4z0c, PDBe:4z0c, PDBj:4z0c
PDBsum	4z0c
PubMed	26323037
UniProt	Q6R5N8\|TLR13_MOUSE Toll-like receptor 13 (Gene Name=Tlr13)

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