Structure of PDB 4ywt Chain D

Receptor sequence
>4ywtD (length=429) Species: 9606 (Homo sapiens) [Search protein sequence]
SRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLA
NRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPG
AFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQL
HPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLG
VASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKG
CLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINAL
QDNRDTLTAKVIQGCGNPKVNRGKLAPRERPPSGTLEKLVSEAKAQLRDV
QDFWISLPGTLCSEKMADRCWNGMARGRYLPEVMGDGLANQINNPEVEVD
ITKPDMTIRQQIMQLKIMTNRLRSAYNGN
3D structure
PDB4ywt Structural Aspects of N-Glycosylations and the C-terminal Region in Human Glypican-1.
ChainD
Resolution2.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA D I437 E443 I392 E398
BS02 CA D D388 D391 D349 D352
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0017134 fibroblast growth factor binding
GO:0043236 laminin binding
Biological Process
GO:0009966 regulation of signal transduction
GO:0014037 Schwann cell differentiation
GO:0016477 cell migration
GO:0030200 heparan sulfate proteoglycan catabolic process
GO:0032288 myelin assembly
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:1905475 regulation of protein localization to membrane
GO:2001016 positive regulation of skeletal muscle cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005768 endosome
GO:0005796 Golgi lumen
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0043202 lysosomal lumen
GO:0045121 membrane raft
GO:0045202 synapse
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0098552 side of membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ywt, PDBe:4ywt, PDBj:4ywt
PDBsum4ywt
PubMed26203194
UniProtP35052|GPC1_HUMAN Glypican-1 (Gene Name=GPC1)

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