Structure of PDB 4yv0 Chain D

Receptor sequence
>4yv0D (length=290) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
ELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWG
TVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLRE
VLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFV
RQTPDNTYDVVIIDTTDPAGPASKLFGEAFYKDVLRILKPDGICCNQGES
IWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVD
VTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN
3D structure
PDB4yv0 Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase
ChainD
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M D L59 Q64 Y73 H74 D98 D118 I119 D149 G150 D168 T169 T170 P175 L179 L55 Q60 Y69 H70 D94 D114 I115 D145 G146 D164 T165 T166 P171 L175
BS02 4JW D W19 Q22 A23 M24 Y237 P238 C239 W15 Q18 A19 M20 Y233 P234 C235 MOAD: ic50=530uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4yv0, PDBe:4yv0, PDBj:4yv0
PDBsum4yv0
PubMed26327378
UniProtQ4DA73

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