Structure of PDB 4yuz Chain D

Receptor sequence
>4yuzD (length=277) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
ELISGGWFREENDPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTV
MALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVL
RHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQ
TPDNTYDVVIIDTGEAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSR
FIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPF
AKDLKYYDSEMHKASFALPRFARHINN
3D structure
PDB4yuz Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase.
ChainD
Resolution1.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M D Q40 Q64 G95 D98 D118 I119 D168 T169 Q34 Q58 G89 D92 D112 I113 D162 T163
BS02 4JV D E14 M24 S25 L26 W53 P235 T236 E10 M18 S19 L20 W47 P218 T219 MOAD: ic50=9.1uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4yuz, PDBe:4yuz, PDBj:4yuz
PDBsum4yuz
PubMed26327378
UniProtQ4DA73

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