Structure of PDB 4yb4 Chain D

Receptor sequence
>4yb4D (length=333) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence]
AYRICLIEGDGIGHEVIPAARRVLEATGLPLEFVEAEAGWETFERRGTSV
PEETVEKILSCHATLFGAATSPTRKVPGFFGAIRYLRRRLDLYANVRPAK
SRPVPGSRPGVDLVIVRENTEGLYVEQERRYLDVAIADAVISKKASERIG
RAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDI
IVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAAGLVGGLGLAPSGNIGD
TTAVFEPVHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVEKAV
DLVLERGPRTPDLGGDATTEAFTEAVVEALKSL
3D structure
PDB4yb4 Structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate, magnesium(II) and NADH
ChainD
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y125 K171 D204 D228 D232
Catalytic site (residue number reindexed from 1) Y124 K170 D203 D227 D231
Enzyme Commision number 1.1.1.286: isocitrate--homoisocitrate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 48Y D K171 N173 V174 K170 N172 V173
BS02 NAI D I202 N205 I201 N204
BS03 48Y D S72 R85 R88 R98 R118 Y125 D228 S71 R84 R87 R97 R117 Y124 D227
BS04 NAI D I13 F67 A70 T71 S72 I84 L241 E257 H260 G261 S262 A263 D265 I266 N273 I12 F66 A69 T70 S71 I83 L240 E256 H259 G260 S261 A262 D264 I265 N272
Gene Ontology
Molecular Function
GO:0004449 isocitrate dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0047046 homoisocitrate dehydrogenase activity
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0009085 lysine biosynthetic process
GO:0019878 lysine biosynthetic process via aminoadipic acid

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Molecular Function
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Biological Process
External links
PDB RCSB:4yb4, PDBe:4yb4, PDBj:4yb4
PDBsum4yb4
PubMed
UniProtQ72IW9|HICDH_THET2 Isocitrate/homoisocitrate dehydrogenase (Gene Name=hicd)

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