Structure of PDB 4y94 Chain D

Receptor sequence
>4y94D (length=153) Species: 9913 (Bos taurus) [Search protein sequence]
GMATVILESIFLKRSQPLNFKKRLFLLTVQKLSYYEYDFERGRRGSKKGS
IDVEKITCVETVVPEKNPPPERQIEQISIIERFPYPFQVVYDEGPLYVFS
PTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGC
QIL
3D structure
PDB4y94 Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.
ChainD
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IHP D K12 S14 Q15 N24 R28 K53 K13 S15 Q16 N19 R23 K48 MOAD: Kd=238nM
BS02 IHP D Y40 R49 K52 Y35 R44 K47 MOAD: Kd=238nM
BS03 ZN D H143 C154 C155 C165 H128 C139 C140 C150
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:4y94, PDBe:4y94, PDBj:4y94
PDBsum4y94
PubMed25699547
UniProtQ3ZC95

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