Structure of PDB 4y6k Chain D

Receptor sequence
>4y6kD (length=237) Species: 368407 (Methanoculleus marisnigri JR1) [Search protein sequence]
WLPLLGMPLMLLFVQIIAIVLVMPMQAPSSVANPLIFIGMLLAFTLVLLV
LLRTGGRRFIAAFIGFALFMTFLYIFGALSLLALGPTTAAAAGTLIGAVA
VTALLYLYPEWYVIDILGVLISAGVASIFGISLEPLPVLVLLVLLAVYDA
ISVYRTKHMITLAEGVGAFVMGMGDLIMPSILVVSSHVFVSAPTLGAMVG
SLVGLAVLLYFVNKGNPQAGLPPLNGGAILGFLVGAA
3D structure
PDB4y6k Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH
ChainD
Resolution3.855 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4B5 D L158 A159 Y161 D162 V215 M216 M223 L275 N279 L145 A146 Y148 D149 V170 M171 M178 L221 N225
Gene Ontology
Molecular Function
GO:0042500 aspartic endopeptidase activity, intramembrane cleaving
GO:0042802 identical protein binding
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4y6k, PDBe:4y6k, PDBj:4y6k
PDBsum4y6k
PubMed25733893
UniProtA3CWV0

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