Structure of PDB 4xz2 Chain D

Receptor sequence

>4xz2D (length=725) Species: 9606 (Homo sapiens) [Search protein sequence]

AIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIA
EADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVI
GGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSID
NDFMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSA
LACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQ
NKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEA
VIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDA
VRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAV
RSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGT
KRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFC
VPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFI
IETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTT
IQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPS
PFDRNFGTKISARAMEWITAKLKETTDDSICVLGISKRNVIFQPVAELKK
QTDFEHRIPKEQWWLKLRPLMKILA

3D structure

PDB

4xz2 Crystal structure of human platelet phosphofructokinase-1 locked in an activated conformation.

Chain

Resolution

2.67 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	G34 R97 C98 D128 G172 S173 D175 D177 R219
Catalytic site (residue number reindexed from 1)	G9 R72 C73 D103 G147 S148 D150 D152 R190
Enzyme Commision number	2.7.1.11: 6-phosphofructokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ADP	D	G33 Y64 R97 C98 R102 G127 G129 S130 G133	G8 Y39 R72 C73 R77 G102 G104 S105 G108
BS02	FBP	D	R481 S540 M583 H671 Q674	R452 S511 M554 H642 Q645
BS03	F6P	D	D175 M217 R219 E273 H307 R310	D150 M188 R190 E244 H278 R281
BS04	PO4	D	R430 R434 G467 G468	R401 R405 G438 G439
BS05	PO4	D	R44 R48 S83 S84 K567 R632	R19 R23 S58 S59 K538 R603

Gene Ontology

	Molecular Function
GO:0003872	6-phosphofructokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016208	AMP binding
GO:0016301	kinase activity
GO:0042802	identical protein binding
GO:0044877	protein-containing complex binding
GO:0045296	cadherin binding
GO:0046872	metal ion binding
GO:0048029	monosaccharide binding
GO:0070095	fructose-6-phosphate binding

	Biological Process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006096	glycolytic process
GO:0016310	phosphorylation
GO:0030388	fructose 1,6-bisphosphate metabolic process
GO:0061621	canonical glycolysis
GO:1990830	cellular response to leukemia inhibitory factor

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005945	6-phosphofructokinase complex
GO:0016020	membrane
GO:0070062	extracellular exosome

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4xz2, PDBe:4xz2, PDBj:4xz2
PDBsum	4xz2
PubMed	26205495
UniProt	Q01813\|PFKAP_HUMAN ATP-dependent 6-phosphofructokinase, platelet type (Gene Name=PFKP)

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