Structure of PDB 4xs2 Chain D

Receptor sequence
>4xs2D (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
RFHSFSFYELKNVTNNFDERPIGNKMGEGGVVYKGYVNNTTVAVKKLAAE
ELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRL
SCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFT
AKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLE
IITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAM
YSVASQCLHEKKNKRPDIKKVQQLLQEMTA
3D structure
PDB4xs2 Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4.
ChainD
Resolution2.73 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D311 K313 A315 N316 D329 T351
Catalytic site (residue number reindexed from 1) D137 K139 A141 N142 D155 T172
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 42P D M192 G193 E194 A211 K213 Y262 Y264 M265 P266 G268 S269 A315 L318 D329 M26 G27 E28 A43 K45 Y88 Y90 M91 P92 G94 S95 A141 L144 D155
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4xs2, PDBe:4xs2, PDBj:4xs2
PDBsum4xs2
PubMed25870132
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

[Back to BioLiP]