Structure of PDB 4xdk Chain D

Receptor sequence
>4xdkD (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHV
CVSPQELETLIQHALDADNAGVSPIGNSSHWDLGSAFFFAGTVITTIGYG
NIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIVISTILF
ILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAG
INREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKE
3D structure
PDB4xdk K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
ChainD
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K D I173 G174 Y175 V282 G283 F284 I97 G98 Y99 V188 G189 F190
BS02 K D T172 I173 T281 V282 T96 I97 T187 V188
BS03 K D T172 T281 T96 T187
BS04 408 D I194 I197 P198 I118 I121 P122
BS05 405 D I194 P198 I118 P122
BS06 408 D L279 F316 L185 F221
BS07 405 D L279 L313 F316 L185 L218 F221
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:4xdk, PDBe:4xdk, PDBj:4xdk
PDBsum4xdk
PubMed25766236
UniProtP57789|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)

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