Structure of PDB 4x2v Chain D

Receptor sequence
>4x2vD (length=171) Species: 223997 (Murine norovirus 1) [Search protein sequence]
VSIWSRVVQFGTGWGFWVSGHVFITAKHVAPPKGTEIFGRKPGDFTVTSS
GDFLKYYFTSAVRPDIPAMVLENGCQEGVVASVLVKRASGEMLALAVRMG
SQAAIKIGSAVVHGQTGMLLTGSNAKAQDLGTIPGDAGCPYVYKKGNTWV
VIGVHVAATRSGNTVIAATHG
3D structure
PDB4x2v Structure determination of Murine Norovirus NS6 proteases with C-terminal extensions designed to probe protease-substrate interactions.
ChainD
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D I107 I109 I105 I107
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4x2v, PDBe:4x2v, PDBj:4x2v
PDBsum4x2v
PubMed25755927
UniProtQ80J95|POLG_MNV1 Genome polyprotein (Gene Name=ORF1)

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