Structure of PDB 4x1y Chain D

Receptor sequence

>4x1yD (length=430) Species: 9940 (Ovis aries) [Search protein sequence]

REIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYY
NEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNW
AKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLL
ISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYS
IDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLR
KLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMA
ACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKT
AVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGE
GMDEMEFTEAESNMNDLVSEYQQYQDATAD

3D structure

PDB

4x1y Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.

Chain

Resolution

3.19 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GDP	D	G10 Q11 C12 Q15 S140 G143 G144 T145 G146 E183 N206 Y224 N228	G9 Q10 C11 Q14 S137 G140 G141 T142 G143 E180 N203 Y221 N225
BS02	LOC	D	C241 K254 L255 N258 M259 T314 A316 N350 K352	C238 K251 L252 N255 M256 T311 A313 N347 K349
BS03	3WV	D	Q11 Q15 V177 S178 D179 P222 T223 Y224	Q10 Q14 V174 S175 D176 P219 T220 Y221

Gene Ontology

	Molecular Function
GO:0003924	GTPase activity
GO:0005200	structural constituent of cytoskeleton
GO:0005525	GTP binding
GO:0046872	metal ion binding

	Biological Process
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0007017	microtubule-based process

	Cellular Component
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005874	microtubule

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4x1y, PDBe:4x1y, PDBj:4x1y
PDBsum	4x1y
PubMed	25431858
UniProt	D0VWY9

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