Structure of PDB 4wpf Chain D

Receptor sequence
>4wpfD (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSM
WEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLV
RMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFS
EDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSIL
AKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTE
3D structure
PDB4wpf Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.
ChainD
Resolution2.202 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D K336 Q346 P500 E504 K73 Q83 P237 E241
BS02 3SN D Q286 L287 W317 C320 L324 M365 A368 F377 F378 F388 I397 Q23 L24 W54 C57 L61 M102 A105 F114 F115 F125 I134 MOAD: ic50=0.25uM
BindingDB: EC50=69nM,IC50=249nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wpf, PDBe:4wpf, PDBj:4wpf
PDBsum4wpf
PubMed25815138
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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