Structure of PDB 4wlo Chain D

Receptor sequence
>4wloD (length=314) Species: 9606 (Homo sapiens) [Search protein sequence]
NAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIET
KAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVAT
LTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLD
IVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQL
TALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVV
ECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPEL
KASIKKGEDFVKTL
3D structure
PDB4wlo Crystal structure of oxaloacetate and NADH bound MDH2
ChainD
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D173 H200
Catalytic site (residue number reindexed from 1) D150 H177
Enzyme Commision number 1.1.1.37: malate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI D S33 G34 G35 I36 D57 P99 A100 G101 V102 P103 I120 I140 N142 H200 M251 S10 G11 G12 I13 D34 P76 A77 G78 V79 P80 I97 I117 N119 H177 M228
BS02 OAA D R104 R110 N142 R176 H200 G234 R81 R87 N119 R153 H177 G211
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016615 malate dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060 L-malate dehydrogenase (NAD+) activity
GO:0042802 identical protein binding
GO:0046554 L-malate dehydrogenase (NADP+) activity
Biological Process
GO:0006094 gluconeogenesis
GO:0006099 tricarboxylic acid cycle
GO:0006108 malate metabolic process
GO:0006734 NADH metabolic process
GO:0009060 aerobic respiration
GO:0019752 carboxylic acid metabolic process
GO:0043490 malate-aspartate shuttle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wlo, PDBe:4wlo, PDBj:4wlo
PDBsum4wlo
PubMed
UniProtP40926|MDHM_HUMAN Malate dehydrogenase, mitochondrial (Gene Name=MDH2)

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