Structure of PDB 4wbo Chain D

Receptor sequence
>4wboD (length=491) Species: 9913 (Bos taurus) [Search protein sequence]
SRDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTH
EQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSFLDAE
TVARARALFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGE
DWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMV
EKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNP
GFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLG
LAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIA
ARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEK
RLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKNIQDV
KGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVW
3D structure
PDB4wbo Identification and characterization of amlexanox as a g protein-coupled receptor kinase 5 inhibitor.
ChainD
Resolution2.81 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D314 K316 E318 N319 D332 A341 T352
Catalytic site (residue number reindexed from 1) D280 K282 E284 N285 D298 A307 T318
Enzyme Commision number 2.7.11.14: rhodopsin kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANW D L193 A214 M264 T265 M267 L321 Y477 A478 L159 A180 M230 T231 M233 L287 Y443 A444
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G protein-coupled receptor kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0050254 rhodopsin kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0009966 regulation of signal transduction
GO:0016310 phosphorylation
GO:0022400 regulation of opsin-mediated signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042995 cell projection
GO:0097381 photoreceptor disc membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wbo, PDBe:4wbo, PDBj:4wbo
PDBsum4wbo
PubMed25340299
UniProtP28327|GRK1_BOVIN Rhodopsin kinase GRK1 (Gene Name=GRK1)

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