Structure of PDB 4w4u Chain D

Receptor sequence
>4w4uD (length=409) Species: 889517 (Saccharomyces cerevisiae CEN.PK113-7D) [Search protein sequence]
MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCH
EINSGATFMCLQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCE
DYIGNIDLINDAILAKYWDDVCTKTMVPSMERRDGLSGLINTCFMSSILQ
CLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGALGFIYL
LTCAWKQDAHEFWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVF
EGSLESSIVNSKTTIDPFLDLSLDIKDKKKLYECLDSFHKKEQAIKQLGI
HKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTVPDIIYE
LIGIVSHKGTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYL
LFYTIRQVN
3D structure
PDB4w4u Uncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity.
ChainD
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H427 N443
Catalytic site (residue number reindexed from 1) H365 N381
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C4 H6 C96 C99 C4 H6 C96 C99
BS02 ZN D H170 C174 C182 C185 H167 C171 C179 C182
BS03 ZN D H250 C271 C273 H276 H221 C242 C244 H247
BS04 ZN D C46 C49 C68 H73 C46 C49 C68 H73
BS05 ZN D C60 C63 H77 H83 C60 C63 H77 H83
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0008234 cysteine-type peptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:4w4u, PDBe:4w4u, PDBj:4w4u
PDBsum4w4u
PubMed25526805
UniProtN1P0J5

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