Structure of PDB 4v8w Chain D

Receptor sequence

>4v8wD (length=2452) Species: 1773 (Mycobacterium tuberculosis)

SSYAPTVVKLPDGSVKLETKFTRLTGRSPILLAGMTPTTVDAKIVAAAAN
AGHWAELAGGGQVTEQIFNDRIAELETLLEPGRAIQFNTLFLDPYLWKLQ
VGGKRLVQRARQSGAPIDGLVVSAGIPDLEEAVDIIDELNEVGISHVVFK
PGTVEQIRSVIRIAAEVPTKPVIVHIEGGRAGGHHSWEDLDDLLLATYSE
LRSRSNITICVGGGIGTPERSAEYLSGRWAEVHGYPLMPIDGILVGTAAM
ATLEATTSPQVKQLLVETKGTEAWVGAGKAANGMASGRSQLGADIHEIDN
AASRCGRLLDEVAGDADAVAERRDEIIAAMAQTAKPYFGDVAEMTYLQWL
RRYVELAIGDGNSTADTKRPDSPWLDITWRDRFEQMLKRAEARLHPQDFG
PIETLFDADADGERLLEDPEAAITALLQRYPDAETVVLHPADVPFFVELC
KTLGKPVNFVPVIDKDVRRWWRSDSLWQAHDARYEADQVCVIPGTAAVAG
ITRVDEPVGELLDRFEQAAVDEVLGAGAEPVEVLSRRQARRDASGPLAVV
LDAPDVLWAGRMSVNPVHRIAAPTEWQVREGSDNRSASHPSTGARLEVAD
DQHVVLSVPLSGTWIEIRFTLTDVVRSGGAPIVEVDDAATAMRAVLAIAA
GVEGPENLPKVVDNTATVTVDWDPERVADHTGVTATFGAPLAPTLTVVPD
ALVGRCWPAVFAAIGSAATEAGFPVIEGLLSLVHLDHAARLLAELPKEPA
EFTVTAKASAATDTEVGRVVPVSVEVRNAADGALLATLEERFAIRGRTGA
AELTDPVRAGGAISDNATDTPRRRRRDVTVGAPVDMRPFAVVSGDHNPIH
TDRAAALLAGLEGPIVHGMWLSAAAQHVVTATDGKPVPPAKLIGWTARFL
GMVKPGDQVDFRVDRVGIDVGAEVLEVSARIGSELVMAATARLAAPKTVY
AFPGQGIQHKGMGMEVRARSKAARKVWDSADKFTRETLGFSVLHVVRDNP
TSLIASGVHYHHPDGVLFLTQFTQVAMATVAAAQVAEMREQGAFVEGAIA
CGHSVGEYTALACVSGVYELEALLEVVFHRGSKMHDIVPRDELGRSNYRL
AAIRPSQIDLDDADVKDFVAEISERTGEFLEIVNFNLRGSQYAIAGTVAG
LEALEEEIERRRQITGGKRSFILVPGIDVPFHSSVLRVGVADFRRSLERV
MPRDKDPELIIGRYIPNLVPRPFTLDRDFIQEIRDLVPAEPLDEVLADYD
TWRNEKPKELCRKVVIELLAWQFASPVRWIETQDLLFIEEAAGGLGVERF
VEIGVKSAPTVAGLATNTLKLPEYSHSTVEVLNSERDAAVLFATDSAALG
EFAEKVTGPDGVLASAARLVLNQLGLSDVVTTPEAATDAELIDLVTAELG
SDWPRLVAPTFDARKAVVFDDRWASAREDLVKLWLAEEGDIDAQWEQLSQ
RFEGTGHVVATQANWWQGKALAAGRNVHASLFGRIAAGAENPGKGRYSDE
VAVVTGASKGSIAASVVGQLLDGGATVIATTSRLDDDRLAFYKQLYRDHA
RFDATLWVVPANMASYSDIDKLVEWVGTEQTESLGPQSIHLKDAQTPTLL
FPFAAPRVAGDMSEVGSRAEMEMKVLLWAVQRLISGLSKIGAERDIASRL
HVVLPGSPNRGMFGGDGAYGEAKSALDALENRWSAEKSWAERVSLAHALI
GWTKGTGLMGQNDAIVSAVEEAGVTTYTTDEMAAMLLDLCTVETKVAAAG
APVKVDLTGGLGDIKIDMAELAAKAREEMSGAADESDDEAPAGTIRALPS
PPRGYNPAPAPEWDDLDVDPADLVVIVGGAELGPYGSSRTRFEMEVSGEL
SAAGVLELAWTTGMVKWEDDPKAGWYDTETGELVPECEIVERYHDAVVER
CGIREFVDDGAIDPDHASPLLVSVFLDKDFTFVVSSEADARAFVQFDPEH
TVARPLPDSSDWEVTRKAGTEIRVPRKTKLSRTVGAQIPTGFDPTVWGIS
PDMASSIDRVALWNIVATVDAFLSSGFTPTELMRWVHPSQVASTQGTGMG
GMTSMQTMYHGNLLGRAKPNDILQEVLPNVVAAHVMQSYVGGYGAMVHPV
GACATAAVSVEEGVDKIKLGKADLVIAGGFDDLTLEAIIGFGDMAATADT
EMMRAKGISDSKFSRANDRRRLGFLEAQGGGTILLARGDLALKMGLPVLA
VVGYAQSFADGVHTSIPAPGLGALGAARGGRESTLARSLAQLGVGADDIA
VISKHDTSTLANDPNETELHERIADSMGRAPGNPLFIVSQKTLTGHAKGG
AAVFQMMGLCQILRDGVIPPNRSLDCVDDELATSGHFVWVREPLDLRGKF
PLKAGLVTSLGFGHVSGLVALVHPEAFIAALDPSEREDYRTRAEQRMLAG
QRRLVSAIAGGRPMYEKPADRRFDHDVPEKRQEAAMLLSTDARLGENDQY
VL

3D structure

• PDB: 4v8w Structure and Conformational Variability of the Mycobacterium Tuberculosis Fatty Acid Synthase Multienzyme Complex.
• Chain: D
• Resolution: 17.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FMN	D	G434 M435 T436 P437 L490 S523 K550 E577 A581 G613 G614 G646 T647 I892	G34 M35 T36 P37 L90 S123 K150 E177 A181 G213 G214 G246 T247 I492

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Thu Nov 28 11:22:31 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '4v8w', asym_id = 'D', title = 'Structure and Conformational Variability of the ...rculosis Fatty Acid Synthase Multienzyme Complex.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='4v8w', asym_id='D', title='Structure and Conformational Variability of the ...rculosis Fatty Acid Synthase Multienzyme Complex.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0004312,0004318,0005835,0006633,0016740,0016746', uniprot = '', pdbid = '4v8w', asym_id = 'D'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0004312,0004318,0005835,0006633,0016740,0016746', uniprot='', pdbid='4v8w', asym_id='D')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>