Structure of PDB 4uxj Chain D

Receptor sequence
>4uxjD (length=159) Species: 5664 (Leishmania major) [Search protein sequence]
RGRIELIIGPMFAGKTTELMRRVKREIHARRSCFVIKYLRAQAAVSQLTE
VRDTWKRFDVLAIDEGQFFSDLVDFCNTAADAGKVVMVSALDGDYRRKPF
GQICELVPYCEAVDKLTAVCMMCHEQPACFTRRTVNVEQQELIGGADMYI
ATCRECYSK
3D structure
PDB4uxj Structural and Kinetic Characterization of Thymidine Kinase from Leishmania Major.
ChainD
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.21: thymidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C140 C143 C173 C176 C120 C123 C153 C156
BS02 TTP D M13 F14 A15 G16 K17 T18 E85 F88 L111 D114 Y115 T151 Q160 E161 L162 G164 Y169 M11 F12 A13 G14 K15 T16 E65 F68 L91 D94 Y95 T131 Q140 E141 L142 G144 Y149
Gene Ontology
Molecular Function
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4uxj, PDBe:4uxj, PDBj:4uxj
PDBsum4uxj
PubMed25978379
UniProtQ4QC75

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