Structure of PDB 4uvh Chain D

Receptor sequence
>4uvhD (length=258) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDLIQRITDRL
PAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMG
INPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRA
MPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLGALGEEA
GAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYAD
GGAHTQLL
3D structure
PDB4uvh Hitting the Target in More Than One Way: Novel, Direct Inhibitors of Mycobacterium Tuberculosis Enoyl Acp Reductase
ChainD
Resolution1.89 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y158 K165
Catalytic site (residue number reindexed from 1) Y154 K161
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD D G14 I16 S20 I21 D64 V65 S94 I95 I122 M147 D148 K165 A191 P193 I194 G13 I15 S19 I20 D60 V61 S90 I91 I118 M143 D144 K161 A187 P189 I190
BS02 UUD D G96 F97 M98 G92 F93 M94
Gene Ontology
Molecular Function
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0005504 fatty acid binding
GO:0016491 oxidoreductase activity
GO:0050343 trans-2-enoyl-CoA reductase (NADH) activity
GO:0070403 NAD+ binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0030497 fatty acid elongation
GO:0046677 response to antibiotic
GO:0071768 mycolic acid biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4uvh, PDBe:4uvh, PDBj:4uvh
PDBsum4uvh
PubMed
UniProtP9WGR1|INHA_MYCTU Enoyl-[acyl-carrier-protein] reductase [NADH] (Gene Name=inhA)

[Back to BioLiP]