Structure of PDB 4unc Chain D

Receptor sequence

>4uncD (length=192) [Search protein sequence]

NENVSGISAYLLGLIIGDGGLYKLKYKGNRSEYRVVITQKSENLIKQHIA
PLMQFLIDELNVKSKIQIVKGDTRYELRVSSKKLYYYFANMLERIRLFNM
REQIAFIKGLYVAEGDKTLKRLRIWNKNKALLEIVSRWLNNLGVRNTIHL
DDHRHGVYVLNISLRDRIKFVHTILSSHLNPLPPEAAALEHH

3D structure

PDB

4unc Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	D	D21 T41 Q42 K43 T76 R77 R124 T150 H152 D154 R157 S166 L167	D18 T38 Q39 K40 T73 R74 R121 T147 H149 D151 R154 S163 L164
BS02	dna	D	N32 R33 S34 E35 Y36 R37 K68 Q70 R81 S83 K85 E117 W128 N129 K130 D155	N29 R30 S31 E32 Y33 R34 K65 Q67 R78 S80 K82 E114 W125 N126 K127 D152
BS03	dna	D	G20 D21 G22 Y25 Y29 R33 R37 R77	G17 D18 G19 Y22 Y26 R30 R34 R74
BS04	dna	D	D21 A116 E117 D119 K120 R126 W128	D18 A113 E114 D116 K117 R123 W125
BS05	dna	D	K86 Y89 N93 R97	K83 Y86 N90 R94
BS06	MN	D	D21 A116	D18 A113
BS07	MN	D	G20 E117	G17 E114
BS08	MN	D	D21 E117	D18 E114

Gene Ontology

	Molecular Function
GO:0004519	endonuclease activity

	Biological Process
GO:0006314	intron homing
GO:0016539	intein-mediated protein splicing

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4unc, PDBe:4unc, PDBj:4unc
PDBsum	4unc
PubMed	25486305
UniProt	P21505\|DMO1_DESMO Homing endonuclease I-DmoI

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