Structure of PDB 4un8 Chain D

Receptor sequence

>4un8D (length=191) [Search protein sequence]

ENVSGISAYLLGLIIGDGGLYKLKYKGNRSEYRVVITQKSENLIKQHIAP
LMQFLIDELNVKSKIQIVKGDTRYELRVSSKKLYYYFANMLERIRLFNMR
EQIAFIKGLYVAEGDKTLKRLRIWNKNKALLEIVSRWLNNLGVRNTIHLD
DHRHGVYVLNISLRDRIKFVHTILSSHLNPLPPEAAALEHH

3D structure

PDB

4un8 Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	D	G20 D21 G22 Y25 K30 R33 T41 Q42 K43 T76 R77 R124 T150 H152 D154 H156 R157 S166 L167	G16 D17 G18 Y21 K26 R29 T37 Q38 K39 T72 R73 R120 T146 H148 D150 H152 R153 S162 L163
BS02	dna	D	N32 R33 S34 E35 Y36 R37 S67 K68 D75 R81 S83 S84 K85 E117 G118 D119 K120 R124 R126 W128 N129 K130 D155 H158	N28 R29 S30 E31 Y32 R33 S63 K64 D71 R77 S79 S80 K81 E113 G114 D115 K116 R120 R122 W124 N125 K126 D151 H154
BS03	dna	D	K86 Y89 N93 R97	K82 Y85 N89 R93
BS04	MN	D	D21 A116	D17 A112
BS05	MN	D	G20 E117	G16 E113

Gene Ontology

	Molecular Function
GO:0004519	endonuclease activity

	Biological Process
GO:0006314	intron homing
GO:0016539	intein-mediated protein splicing

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Molecular Function

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Biological Process

External links

PDB	RCSB:4un8, PDBe:4un8, PDBj:4un8
PDBsum	4un8
PubMed	25486305
UniProt	P21505\|DMO1_DESMO Homing endonuclease I-DmoI

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