Structure of PDB 4umc Chain D

Receptor sequence
>4umcD (length=333) Species: 122586 (Neisseria meningitidis MC58) [Search protein sequence]
ELLPPIAHLYELPISKEASGLVHRTRQEISDLVHGRDKRLLVIIGPCSIH
DPKAALEYAERLLKLRKQYENELLIVMRVYFEKPRTTVGWKGLINDPHLD
GTFDINFGLRQARSLLLSLNNMGMPASTEFLDMITPQYYADLISWGAIGA
RTTESQVHRELASGLSCPVGFKNGTDGNLKIAIDAIGAASHSHHFLSVTK
AGHSAIVHTGGNPDCHVILRGGKEPNYDAEHVSEAAEQLRAAGVTDKLMI
DCSHANSRKDYTRQMEVAQDIAAQLEQDGGNIMGVMVESHLVEGRQDKPE
VYGKSITDACIGWGATEELLALLAGANKKRMAR
3D structure
PDB4umc Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water.
ChainD
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN D C63 H270 E304 D324 C47 H254 E288 D308
BS02 PEQ D R94 K99 R167 K188 R236 H270 R78 K83 R151 K172 R220 H254 MOAD: Ki=360uM
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4umc, PDBe:4umc, PDBj:4umc
PDBsum4umc
PubMed25245459
UniProtQ9K169

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