Structure of PDB 4tr9 Chain D

Receptor sequence
>4tr9D (length=347) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
EYMNAPKKLPADVAEELATTAQKLVQAGKGILAADESTQTIKKRFDNIKL
ENTIENRASYRDLLFGTKGLGKFISGAILFEETLFQKNEAGVPMVNLLHN
ENIIPGIKVDKGLVNIPCTDEEKSTQGLDGLAERCKEYYKAGARFAKWRT
VLVIDTAKGKPTDLSIHETAWGLARYASICQQNRLVPIVEPEILADGPHS
IEVCAVVTQKVLSCVFKALQENGVLLEGALLKPNMVTAGYECTAKTTTQD
VGFLTVRTLRRTVPPALPGVVFLSGGQSEEEASVNLNSINALGPHPWALT
FSYGRALQASVLNTWQGKKENVAKAREVLLQRAEANSLATYGKYKGG
3D structure
PDB4tr9 Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex.
ChainD
Resolution2.111 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D39 K151 E194 E196 K236 S306
Catalytic site (residue number reindexed from 1) D35 K147 E190 E192 K232 S302
Enzyme Commision number 4.1.2.13: fructose-bisphosphate aldolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D A37 E40 R48 E196 S278 G279 R309 Q312 A33 E36 R44 E192 S274 G275 R305 Q308
BS02 38D D D39 T44 K112 K151 D35 T40 K108 K147
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0004332 fructose-bisphosphate aldolase activity
GO:0016829 lyase activity
Biological Process
GO:0006096 glycolytic process
GO:0008154 actin polymerization or depolymerization
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0020002 host cell plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4tr9, PDBe:4tr9, PDBj:4tr9
PDBsum4tr9
PubMed26289816
UniProtQ7KQL9|ALF_PLAF7 Fructose-bisphosphate aldolase (Gene Name=FBPA)

[Back to BioLiP]