Structure of PDB 4to5 Chain D

Receptor sequence

>4to5D (length=480) Species: 9606 (Homo sapiens)

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARD
CHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSL
HRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAY
TKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIK
REDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVS
FYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYF
VQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

• PDB: 4to5 Structural basis of cellular dNTP regulation by SAMHD1.
• Chain: D
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GTP	D	K116 V117 I118 D137 R145	K4 V5 I6 D25 R33
BS02	TTP	D	V117 N119	V5 N7
BS03	DCP	D	Q149 L150 R164 R206 H210 H215 D311 K312 Y315 D319 R366 Y374	Q37 L38 R52 R94 H98 H103 D192 K193 Y196 D200 R247 Y255
BS04	GTP	D	Y155 V156 V378 R451 K455	Y43 V44 V259 R332 K336
BS05	TTP	D	R333 R352 K354 K523	R214 R233 K235 K404
BS06	TTP	D	V156 F157 R372 H376 K377	V44 F45 R253 H257 K258

External links

• PDB: RCSB:4to5, PDBe:4to5, PDBj:4to5
• PDBsum: 4to5
• PubMed: 25267621
• UniProt: Q9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)