Structure of PDB 4to3 Chain D

Receptor sequence

>4to3D (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4to3 Structural basis of cellular dNTP regulation by SAMHD1.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DGT	D	K116 V117 I118 D137 R145	K4 V5 I6 D25 R33
BS02	DGT	D	V156 F157 R372 H376 K377	V44 F45 R254 H258 K259
BS03	DGT	D	V117 N119	V5 N7
BS04	DGT	D	R333 R352 K354 K523	R215 R234 K236 K405
BS05	DCP	D	Q149 L150 R164 R206 H210 H215 H233 K312 Y315 D319 R366 Y374	Q37 L38 R52 R94 H98 H103 H121 K194 Y197 D201 R248 Y256
BS06	DGT	D	Y155 V156 V378 R451	Y43 V44 V260 R333

External links

PDB	RCSB:4to3, PDBe:4to3, PDBj:4to3
PDBsum	4to3
PubMed	25267621
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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