Structure of PDB 4to0 Chain D

Receptor sequence

>4to0D (length=484) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLESPVLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDY
FARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHT
RNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDD
MEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQ
IKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPI
DHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAA
RQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4to0 Structural basis of cellular dNTP regulation by SAMHD1.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GTP	D	K116 V117 I118 D137 R145	K4 V5 I6 D25 R33
BS02	DTP	D	R333 R352 K354 N358 K523	R218 R237 K239 N243 K408
BS03	DCP	D	Q149 L150 R164 R206 H210 H215 H233 D311 K312 Y315 D319 R366 Y374	Q37 L38 R52 R94 H98 H103 H121 D196 K197 Y200 D204 R251 Y259
BS04	DTP	D	V156 F157 R372 H376 K377	V44 F45 R257 H261 K262
BS05	GTP	D	Y155 V156 V378 R451	Y43 V44 V263 R336

External links

PDB	RCSB:4to0, PDBe:4to0, PDBj:4to0
PDBsum	4to0
PubMed	25267621
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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