Structure of PDB 4tnp Chain D

Receptor sequence

>4tnpD (length=484) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLESPVLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDY
FARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHT
RNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDD
MEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQ
IKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPI
DHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAA
RQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4tnp Structural basis of cellular dNTP regulation by SAMHD1.

Chain

Resolution

2.0 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GTP	D	K116 V117 I118 D137 R145	K4 V5 I6 D25 R33
BS02	DCP	D	R333 R352 K354 K523	R218 R237 K239 K408
BS03	DCP	D	Q149 L150 R164 R206 H210 H215 H233 D311 K312 Y315 D319 R366 Y374	Q37 L38 R52 R94 H98 H103 H121 D196 K197 Y200 D204 R251 Y259
BS04	DCP	D	V156 F157 R372 H376 K377	V44 F45 R257 H261 K262
BS05	GTP	D	Y155 V156 V378 R451 K455	Y43 V44 V263 R336 K340

External links

PDB	RCSB:4tnp, PDBe:4tnp, PDBj:4tnp
PDBsum	4tnp
PubMed	25267621
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

[Back to BioLiP]