Structure of PDB 4tmc Chain D

Receptor sequence
>4tmcD (length=396) Species: 4911 (Kluyveromyces marxianus) [Search protein sequence]
MSYMNFDPKPLGDTNIFKPIKIGNNELKHRVVMPALTRMRAIAPGNIPNT
EWAEEYYRQRSQYPGTLIITEGTFPSAQSGGYPNVPGIWSKEQLAEWKKI
FNAIHENKSFVWVQLWVLGRQAWPEVLKKEGLRYDSATDDLYMGEEEKER
ALKANNPQHGITKEEIKQYIKEYVDAAKKAIDAGADGVQIHSANGYLLNQ
FLDPISNNRTDEYGGSIENRARFTLEVVDAVVDAVGAERTSIRFSPYGTF
GTMSGGENPGIVAQYAYVIGELEKRARAGKRLAFIDLVEPRVTDPFLPEF
EKWFKEGTNEFIYSIWKGPVLRVGNYALDPDQATLDSKKPNTLIGYGRSF
IANPDLVYRLEKGLPLNKYDRNTFYTFTKEGYTDYPSYEESVAKGY
3D structure
PDB4tmc An Engineered Old Yellow Enzyme that Enables Efficient Synthesis of (4R,6R)-Actinol in a One-Pot Reduction System
ChainD
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T37 H191 N194 Y196 R243 G251
Catalytic site (residue number reindexed from 1) T37 H191 N194 Y196 R243 G251
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN D A35 L36 T37 G72 Q114 H191 N194 R243 V292 V323 G324 N325 G347 R348 F374 Y375 A35 L36 T37 G72 Q114 H191 N194 R243 V292 V323 G324 N325 G347 R348 F374 Y375
BS02 HBA D W116 H191 N194 Y196 Y375 W116 H191 N194 Y196 Y375
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003959 NADPH dehydrogenase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:4tmc, PDBe:4tmc, PDBj:4tmc
PDBsum4tmc
PubMed25639703
UniProtQ6I7B7

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