Structure of PDB 4tkg Chain D

Receptor sequence
>4tkgD (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
FQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRK
EVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAIGGMFGAGIYFAENS
SKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKM
AHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
3D structure
PDB4tkg Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
ChainD
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C1081 H1084 C1089 C1092 C116 H119 C124 C127
BS02 09L D H1031 G1032 H1048 A1049 G1058 I1059 Y1060 F1061 S1068 Y1071 E1138 H67 G68 H84 A85 G93 I94 Y95 F96 S103 Y106 E173 BindingDB: IC50=2340nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4tkg, PDBe:4tkg, PDBj:4tkg
PDBsum4tkg
PubMed25286857
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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