Structure of PDB 4tjw Chain D

Receptor sequence
>4tjwD (length=191) Species: 9606 (Homo sapiens) [Search protein sequence]
FQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRK
EVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAEN
SSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMK
MAHSPPGHHSVTGRPALAEYVIYRGEQAYPEYLITYQIMRP
3D structure
PDB4tjw Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
ChainD
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C1081 H1084 C1089 C1092 C117 H120 C125 C128
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4tjw, PDBe:4tjw, PDBj:4tjw
PDBsum4tjw
PubMed25286857
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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