Structure of PDB 4s1c Chain D

Receptor sequence

>4s1cD (length=208) Species: 169963 (Listeria monocytogenes EGD-e) [Search protein sequence]

NHPLLKKILMKAPGTYHHSMMVANLAEACADKIGANSLLVRVGCFYHDIG
KTLRPPYFVENQLQGINPHDRLTPEQSRDIILSHTKDGAEILKENHMPQP
IIDIALQHHGTTLLKYFYFKAKDVKEADYRYSGPKPQTKEIAIINISDSV
EAAVRSSTEPTMAKITEIIDGIIKDRFLDGQFTECDITIQEIKIIRDTLI
ATLNGIYH

3D structure

PDB

4s1c An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.

Chain

Resolution

2.398 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FE	D	D544 H580 H604 H605	D48 H84 H108 H109
BS02	FE	D	H514 H543 D544 D648	H18 H47 D48 D148

External links

PDB	RCSB:4s1c, PDBe:4s1c, PDBj:4s1c
PDBsum	4s1c
PubMed	25583510
UniProt	Q8Y746

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