Structure of PDB 4s1b Chain D

Receptor sequence

>4s1bD (length=214) Species: 169963 (Listeria monocytogenes EGD-e) [Search protein sequence]

ANPNHPLLKKILMKAPGTYHHSMMVANLAEACADKIGANSLLVRVGCFYH
DIGKTLRPPYFVENQLQGINPHDRLTPEQSRDIILSHTKDGAEILKENHM
PQPIIDIALQHHGTTLLKYFYFKAKETNPDVKEADYRYSGPKPQTKEIAI
INISDSVEAAVRSSTEPTMAKITEIIDGIIKDRFLDGQFTECDITIQEIK
IIRDTLIATLNGIY

3D structure

PDB

4s1b An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.

Chain

Resolution

2.099 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FE	D	D544 H580 H604 H605	D51 H87 H111 H112
BS02	FE	D	H514 H543 D544 D648	H21 H50 D51 D155
BS03	2BA	D	H514 D544 K547 F554 V555 E556 I577 H580 H605 L610 F613 Y631 D648 S649 A652 A653	H21 D51 K54 F61 V62 E63 I84 H87 H112 L117 F120 Y138 D155 S156 A159 A160	MOAD: Kd=0.3uM

External links

PDB	RCSB:4s1b, PDBe:4s1b, PDBj:4s1b
PDBsum	4s1b
PubMed	25583510
UniProt	Q8Y746

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