Structure of PDB 4s0n Chain D

Receptor sequence
>4s0nD (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
GPGSVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKV
NNVNGNQVGHLKKELAGALAYIMDNKLAQIEGVVPFGANNAFTMPLHMTF
WGKEENRKAVSDQLKKHGFKLGPAPK
3D structure
PDB4s0n HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.
ChainD
Resolution1.501 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D S62 H147 P173 S12 H97 P123 PDBbind-CN: Kd=13nM
BS02 dna D V68 G69 Y72 Y73 Y93 D94 H110 K112 K113 V18 G19 Y22 Y23 Y43 D44 H60 K62 K63 PDBbind-CN: Kd=13nM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

View graph for
Molecular Function
External links
PDB RCSB:4s0n, PDBe:4s0n, PDBj:4s0n
PDBsum4s0n
PubMed26051180
UniProtQ14527|HLTF_HUMAN Helicase-like transcription factor (Gene Name=HLTF)

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