Structure of PDB 4rz8 Chain D

Receptor sequence
>4rz8D (length=339) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
VWKDADTTLFCASDAKAHETEVHNVWATHACVPTDPNPQEIHLENVTENF
NMWKNNMVEQMQEDVISLWDQSLQPCVKLTGGSVIKQACPKISFDPIPIH
YCTPAGYVILKCNDKNFNGTGPCKNVSSVQCTHGIKPVVSTQLLLNGSLA
EEEIIIRSENLTNNAKTIIVHLNKSVEINCTRPSNGDIRKAYCEINGTKW
NKVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHSFNCRGEFFYCNTTQ
LFNNTCINGTITLPCKIKQIINMWQGTGQAMYAPPIDGKINCVSNITGIL
LTRDGGANNTSNETFRPGGGNIKDNWRSELYKYKVVQIE
3D structure
PDB4rz8 Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity.
ChainD
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3ZM D E370 S375 F376 F382 N425 M426 W427 Q428 G429 E231 S236 F237 F243 N272 M273 W274 Q275 G276 MOAD: ic50~270nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4rz8, PDBe:4rz8, PDBj:4rz8
PDBsum4rz8
PubMed26301736
UniProtA0A0M3KKW9

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