Structure of PDB 4rv8 Chain D

Receptor sequence
>4rv8D (length=327) Species: 5807 (Cryptosporidium parvum) [Search protein sequence]
MGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAM
DTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNSGGLRVGAAIG
VNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNV
VTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVA
SKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIG
DTVYKYYRGMGSVGAMKSKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCM
GYLGSASIEELWKKSSYVEITTDVEIV
3D structure
PDB4rv8 Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity.
ChainD
Resolution2.053 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I13 D S354 G357 Y358 S298 G301 Y302
BS02 I13 D A165 H166 N191 M302 G303 E329 A123 H124 N149 M260 G261 E273
BS03 IMP D S48 M50 G216 S217 I218 C219 D252 G254 M273 G275 S276 Y299 G301 M302 G303 E329 S48 M50 G174 S175 I176 C177 D210 G212 M231 G233 S234 Y257 G259 M260 G261 E273
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4rv8, PDBe:4rv8, PDBj:4rv8
PDBsum4rv8
PubMed25945705
UniProtQ8T6T2|IMDH_CRYPV Inosine-5'-monophosphate dehydrogenase (Gene Name=56k.02)

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