Structure of PDB 4r7u Chain D

Receptor sequence
>4r7uD (length=418) Species: 243277 (Vibrio cholerae O1 biovar El Tor str. N16961) [Search protein sequence]
MEKFRVIGSTQPLQGEVTISGAKNAALPILFASILAEEPVEVANVPHLRD
IDTTMELLERLGAKVERNGSVHVDAGPINQYCAPYDLVKTMRASIWALGP
LVARFGQGQVSLPGGCAIGARPVDLHIHGLEQLGATITLEDGYVKAHVDG
RLQGAHIVMDKVSVGATITIMCAATLAEGTTVLDNAAREPEIVDTAMFLN
KLGAKISGAGTDSITIEGVERLGGGKHAVVPDRIETGTFLVAAAVSRGKI
VCRNTHAHLLEAVLAKLEEAGAEIECGEDWISLDMTGRELKAVTVRTAPH
PGFPTDMQAQFTLLNMMAKGGGVITETIFENRFMHVPELKRMGAKAEIEG
NTVICGDVDRLSGAQVMATDLRASASLVIAGCIAKGETIVDRIYHIDRGY
ERIEDKLSALGANIERFR
3D structure
PDB4r7u Structure of UDP-N-acetylglucosamine 1-carboxyvinyltransferase from Vibrio cholerae in complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin
ChainD
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K23 N24 D50 A93 C116 R121 D306 I328 R398
Catalytic site (residue number reindexed from 1) K23 N24 D50 A93 C116 R121 D306 I328 R398
Enzyme Commision number 2.5.1.7: UDP-N-acetylglucosamine 1-carboxyvinyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UD1 D N24 W96 R121 P122 V123 D124 L125 K161 S163 V164 G165 D306 I328 F329 N24 W96 R121 P122 V123 D124 L125 K161 S163 V164 G165 D306 I328 F329
BS02 FFQ D M91 R92 C116 R398 M91 R92 C116 R398
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008760 UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0019277 UDP-N-acetylgalactosamine biosynthetic process
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4r7u, PDBe:4r7u, PDBj:4r7u
PDBsum4r7u
PubMed
UniProtQ9KP62|MURA_VIBCH UDP-N-acetylglucosamine 1-carboxyvinyltransferase (Gene Name=murA)

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