Structure of PDB 4r1q Chain D

Receptor sequence

>4r1qD (length=496) Species: 235909 (Geobacillus kaustophilus HTA426)

MMLSLRPYEFWFVTGSQHLYGEEALKQVEEHSRIMVNEWNRDSVFPFPFV
FKSVVTTPEEIRRVCLEANASEQCAGVVTWMHTFSPAKMWIGGLLELRKP
LLHLHTQFNRDIPWDSIDMDFMNLNQSAHGDREYGFIGARMGVARKVVVG
HWEDPEVRERLAKWMRTAVAFAESRNLKVARFGDNMREVAVTEGDKVGAQ
IQFGWSVNGYGIGDLVQYIRDVSEQKVNELLDEYEELYDIVPAGRQEGPV
RESIREQARIELGLKAFLQDGNFTAFTTTFEDLHGMKQLPGLAVQRLMAE
GYGFGGEGDWKTAALVRLMKVMADGKGTSFMEDYTYHFEPGNELILGAHM
LEVCPTIAATRPRVEVHPLSIGGKEDPARLVFDGGEGAAVNASLIDLGHR
FRLIVNEVDAVKPEHDMPKLPVARILWKPRPSLRDSAEAWILAGGAHHTC
FSFAVTTEQLQDFAEMAGIECVVINEHTSVSSFKNELKWNEVFWRG

3D structure

• PDB: 4r1q Crystal Structure of Thermophilic L-Arabinose Isomerase with L-Arabitol from Geobacillus kaustophilus
• Chain: D
• Resolution: 2.248 Å

Enzymatic activity

• Enzyme Commision number: 5.3.1.4: L-arabinose isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SST	D	M186 E307 E332 H447	M186 E307 E332 H447
BS02	MN	D	E307 E332 H349 H448	E307 E332 H349 H448
BS03	SST	D	Y20 F84 H129	Y20 F84 H129

Gene Ontology

Molecular Function

• GO:0008733 L-arabinose isomerase activity
• GO:0016853 isomerase activity
• GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0005996 monosaccharide metabolic process
• GO:0019568 arabinose catabolic process
• GO:0019569 L-arabinose catabolic process to xylulose 5-phosphate

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4r1q, PDBe:4r1q, PDBj:4r1q
• PDBsum: 4r1q
• UniProt: Q5KYP7|ARAA_GEOKA L-arabinose isomerase (Gene Name=araA)